What Is 5-Amino-1MQ? The NNMT Inhibitor Explained
5-Amino-1MQ is a small molecule, not a peptide, that blocks an enzyme called NNMT. It links to NAD+ metabolism and has been studied in mice. Here is what it is and how it works.
5-Amino-1MQ in brief
5-Amino-1MQ (5-amino-1-methylquinolinium, also written 5 amino 1mq) is a small molecule, not a peptide. It blocks an enzyme called nicotinamide N-methyltransferase (NNMT). It is sold alongside research peptides because it is used in the same metabolic research.
- Full name
- 5-amino-1-methylquinolinium
- Type
- Small molecule
- Target
- NNMT enzyme
- Mass
- About 159 g/mol
- Our vial
- 10mg
What is NNMT?
NNMT is an enzyme found mainly in the liver and fat tissue. It attaches a methyl group to nicotinamide (a form of vitamin B3). That matters because nicotinamide is recycled into NAD+; every molecule NNMT methylates is one less available for NAD+ recycling. NNMT activity is higher in fat tissue in obesity models, which is why researchers became interested in blocking it.
| Step | What happens |
|---|---|
| 1. Nicotinamide | A vitamin B3 form, normally recycled into NAD+ |
| 2. NNMT acts | Methylates nicotinamide, removing it from recycling |
| 3. 5-Amino-1MQ | Blocks NNMT, leaving more nicotinamide available |
What research has looked at
The best-known study, published in 2018, tested 5-Amino-1MQ in fat cells and in mice fed a high-fat diet, looking at fat-cell metabolism and body composition. Work since then is still mainly in cells and mice; there is no approved medicine based on it.
- BPC-157~1,419
- NAD+~663
- 5-Amino-1MQ~159
5-Amino-1MQ is far smaller than a peptide. NAD+ is shown because NNMT affects its recycling.
Handling
As a small molecule, 5-Amino-1MQ has different solubility from peptides, so follow the supplier's handling notes. We stock 5-Amino-1MQ in 10mg vials.
Further reading
For laboratory research use only. Not for human consumption. Not medical or legal advice.
